Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography
Identifieur interne : 001394 ( Main/Exploration ); précédent : 001393; suivant : 001395Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography
Auteurs : Wan Qin [États-Unis] ; Ruikang K. Wang [États-Unis]Source :
- Lasers in medical science [ 0268-8921 ] ; 2016.
Abstract
Accurate measurement of edema volume is essential for the investigation of tissue response and recovery following a traumatic injury. The measurements must be noninvasive and repetitive over time so as to monitor tissue response throughout the healing process. Such techniques are particularly necessary for the evaluation of therapeutics that are currently in development to suppress or prevent edema formation. In this study, we propose to use optical coherence tomography (OCT) technique to image and quantify edema in a mouse ear model where the injury is induced by a superficial-thickness burn. Extraction of edema volume is achieved by an attenuation compensation algorithm performed on the three-dimensional OCT images, followed by two segmentation procedures. In addition to edema volume, the segmentation method also enables accurate thickness mapping of edematous tissue, which is an important characteristic of the external symptoms of edema. To the best of our knowledge, this is the first method for noninvasively measuring absolute edema volume.
Url:
DOI: 10.1007/s10103-016-1984-x
PubMed: 27282161
PubMed Central: 5287999
Affiliations:
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Wang</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Bioengineering, University of Washington, Seattle, WA 98195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Washington, Seattle, WA 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Ophthalmology, University of Washington, Seattle, WA 98109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of Washington, Seattle, WA 98109</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author></analytic><series><title level="j">Lasers in medical science</title><idno type="ISSN">0268-8921</idno><idno type="eISSN">1435-604X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Accurate measurement of edema volume is essential for the investigation of tissue response and recovery following a traumatic injury. The measurements must be noninvasive and repetitive over time so as to monitor tissue response throughout the healing process. Such techniques are particularly necessary for the evaluation of therapeutics that are currently in development to suppress or prevent edema formation. In this study, we propose to use optical coherence tomography (OCT) technique to image and quantify edema in a mouse ear model where the injury is induced by a superficial-thickness burn. Extraction of edema volume is achieved by an attenuation compensation algorithm performed on the three-dimensional OCT images, followed by two segmentation procedures. In addition to edema volume, the segmentation method also enables accurate thickness mapping of edematous tissue, which is an important characteristic of the external symptoms of edema. To the best of our knowledge, this is the first method for noninvasively measuring absolute edema volume.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Washington (État)</li></region><settlement><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Qin, Wan" sort="Qin, Wan" uniqKey="Qin W" first="Wan" last="Qin">Wan Qin</name></region><name sortKey="Wang, Ruikang K" sort="Wang, Ruikang K" uniqKey="Wang R" first="Ruikang K." last="Wang">Ruikang K. Wang</name><name sortKey="Wang, Ruikang K" sort="Wang, Ruikang K" uniqKey="Wang R" first="Ruikang K." last="Wang">Ruikang K. Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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